Tổng hợp chất lai của 2-aminobenzothiazole có chứa nhóm 2-aminobenzamide qua cầu nối amide
156 lượt xemDOI:
https://doi.org/10.54939/1859-1043.j.mst.81.2022.79-85Từ khóa:
2-aminobenzothiazole; 2-aminobenzamide; Tổng hợp; Độc tế bào; Chất lai.Tóm tắt
Hợp chất lai của 2-aminobenzothiazole có chứa nhóm 2-aminobenzamide qua cầu nối amide đã được thiết kế, tổng hợp thành công và cấu trúc được xác định bằng các phương pháp phổ cộng hưởng từ hạt nhân (NMR), phổ khối lượng phân giải cao (HRMS). Hợp chất (3) tổng hợp cũng đã được thử hoạt tính kháng tế bào ung thư người in vitro trên hai dòng tế bào A549 và SW480. Kết quả thu được cho thấy, hợp chất (3) không thể hiện hoạt tính đối với dòng tế bào SW480 nhưng lại thể hiện độc tính đối với dòng tế bào A549 với giá trị IC50 là 29.49 µM.
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