Cross-Fourier analysis for differentiating prolonged and self-terminating ventricular tachycardia in isolated rat hearts
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https://doi.org/10.54939/1859-1043.j.mst.87.2023.85-93Keywords:
Ventricular tachycardia; Arrhythmia; Bivariate time-series; Mechano-electrical coupling.Abstract
The interaction between the ventricles and atria in the heart is an important aspect of cardiac function. During ventricular arrhythmias, such as ventricular tachycardia and ventricular fibrillation, the atrial interbeat interval appears different from that of normal sinus rhythm, even though there is no direct electrical connection between the ventricles and atria. To understand this phenomenon, bivariate time-series Fourier analysis was performed on ventricular and atrial signals. The results showed different levels of correlation from the ventricles to the atria during ventricular arrhythmias. We found that low interaction was associated with self-terminating ventricular arrhythmias, while strong connections were mostly seen in sustained ventricular arrhythmias. These findings suggest that the underlying mechanism behind this interaction may be due to the presence of mechano-electrical coupling, which serves as a bridge from the ventricles to the atria (reciprocal connections).
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