An iterated map model with CaMKII feedback in modeling the force frequency relationship of a cardiac cell
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https://doi.org/10.54939/1859-1043.j.mst.82.2022.142-149Keywords:
Cardiac myocyte; Feedback; Rat heart; CaMKII; Calcium.Abstract
Experiment data on isolated rat hearts shows that the transient behaviors after switching pacing intervals are very complicated with increasing, decreasing, and rebound of the contraction force. The strength of contraction in the heart muscle is strongly related to intracellular free Ca2+ mediated by an action potential. This behavior can be explained by calcium cycling inside the excitable cardiac myocytes coupled with their action potential. The previous and recently proposed models can only explain a short period of time after changing the pacing frequency. Our aim is to develop a simple feedback model based on the role of the enzyme CaMKII to describe the whole dynamic picture captured from experiments.
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