Synthesis and anti-inflammatory activity evaluation of novel AZT and adenosine derivatives
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https://doi.org/10.54939/1859-1043.j.mst.VITTEP.2022.30-36Keywords:
Adenosine; AZT; Quinazolinone; Click chemistry; Anti-inflammatory.Abstract
A five-step procedure was used to synthesize four novel conjugates of AZT and adenosine with quinazolinone scaffold. In the last step, alkynes-1 of quinazolinone were coupled to adenosine azide and AZT by Click chemistry to yield the designed conjugates. Their structures were characterized by full-length data of spectra including 1H-, 13C-NMR and MS. Screening for their in vitro anti-inflammatory activity was performed using Murine macrophage RAW 264.7 cells. The relationship between structure and biological activity was also discussed.
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