Synthesis of 2-aminobenzothiazole hybrids containing 2-aminobenzamide group via amide bridge
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https://doi.org/10.54939/1859-1043.j.mst.81.2022.79-85Keywords:
2-aminobenzothiazole; 2-aminobenzamide; Synthesis; Cytotoxicity; Hybrids.Abstract
The hybrid compound of 2-aminobenzothiazole containing 2-aminobenzamide group via amide bridge was designed and successfully synthesized, and the structure was determined by the methods of Nuclear Magnetic Resonance (NMR), High resolution - mass spectra (HRMS). The synthesized compound was also evaluated for its anticancer activity in vitro on two cell lines A549 and SW480. The obtained results showed that compound (3) showed no activity against SW480 cell line but showed toxicity against A549 cell line with IC50 value of 29.49 µM.
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