Synthesis of 2-aminobenzothiazole hybrids containing 2-aminobenzamide group via amide bridge



  • Dinh Thi Cuc (Corresponding Author) Graduate University of Science and Technology, Vietnam Academy of Science and Technology
  • Nguyen Thi Hien Institute of Chemistry, Vietnam Academy of Science and Technology
  • Trinh Thu Ha Graduate University of Science and Technology, Vietnam Academy of Science and Technology
  • Tran Dang Thuan Graduate University of Science and Technology, Vietnam Academy of Science and Technology
  • Nguyen Thi Nga Hanoi Medical College
  • Nguyen Thi Kim Tuyet Phu Tho Medical College



2-aminobenzothiazole; 2-aminobenzamide; Synthesis; Cytotoxicity; Hybrids.


The hybrid compound of 2-aminobenzothiazole containing 2-aminobenzamide group via amide bridge was designed and successfully synthesized, and the structure was determined by the methods of Nuclear Magnetic Resonance (NMR), High resolution - mass spectra (HRMS). The synthesized compound was also evaluated for its anticancer activity in vitro on two cell lines A549 and SW480. The obtained results showed that compound (3) showed no activity against SW480 cell line but showed toxicity against A549 cell line with IC50 value of 29.49 µM.


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How to Cite

Đinh Thị Cúc, Nguyễn Thị Hiển, Trịnh Thu Hà, Trần Đăng Thuần, Nguyễn Thị Nga, and Nguyễn Thị Kim Tuyết. “Synthesis of 2-Aminobenzothiazole Hybrids Containing 2-Aminobenzamide Group via Amide Bridge”. Journal of Military Science and Technology, no. 81, Aug. 2022, pp. 79-85, doi:10.54939/1859-1043.j.mst.81.2022.79-85.



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