Heparin - Pluronic F127 Nanogel với tỷ lệ thành phần tối ưu cho các ứng dụng mang thuốc
111 lượt xemDOI:
https://doi.org/10.54939/1859-1043.j.mst.88.2023.58-65Từ khóa:
Nanogel; Cisplatin; Pluronic F127; Paclitaxel.Tóm tắt
Nghiên cứu tổng hợp copolyme trên cơ sở Heparin (Hep) và Pluronic F127 (F127) với tỷ lệ Hep:F127 tối ưu để nang hoá hai hệ thuốc Paclitaxel và cisplatin. Sự tạo thành copolyme của liên hợp Hep-F127 được hình thành thông qua các cầu nối disulfide của các phân tử cystamine. Các hệ Hep-F127 thu được đã được nghiên cứu đặc trưng cấu trúc bằng phương pháp cộng hưởng từ hạt nhân Proton (1H-NMR), thế Zeta và tán xạ ánh sáng động (DLS). Dược chất Cisplatin (CPT) được sử dụng cho mô hình nang hoá dược chất tan trong nước, trong khi Paclitaxel (PTX) được sử dụng cho mô hình nang hoá thuốc kém tan trong nước. Khả năng nang hoá CPT và PTX của hệ nanogel đã được khảo sát để lựa chọn tỷ lệ Hep-F127 tối ưu trong từng mô hình.
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