Study on evaluating 5-fluorouracil loading and releasing of Fe-BDC-PEG materials
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https://doi.org/10.54939/1859-1043.j.mst.FEE.2022.230-236Keywords:
Metal - organic-framework; Drug delivery; 5-fluorouracil; Cancer treatment.Abstract
This paper presents the results of 5 fluorouracil carrying-release of iron (III) framework materials with two ligands of 1,4-benzendiccarboxylic acid and polyethylene glycol diacid synthesized by ultrasonic bath method at an average temperature. Materials before and after 5-fluorouracil were characterized; their properties by scanning electron microscopy (SEM) and infrared spectroscopy (FT-IR) techniques showed that the active ingredient was wholly absorbed into the structural framework of the material without changing the shape and size of the material. The evaluation results for the 5 fluorouracil carrying capacity of Fe-BDC-PEG two-ligand Fe-BDC-PEG framework material showed that the drug absorption capacity reached 358.707 mg/g. The slow release characteristics of the material were also evaluated, showing that the effective release of the active ingredient reached 94.42% after 7 days, and the maximum after 10 days reached 97.68%. The Fe-BDC-PEG@5-FU drug carrier material system is studied to orient the application of cancer treatment when minimizing side effects based on the slow release of the system.
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