Fabrication of alginate microparticles by microfluidic device for vorinostat anti-cancer agent delivery

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Authors

  • Ngo Thi Thuy Trang School of Chemical Engineering, Hanoi University of Science and Technology
  • Dang Cu Trung School of Chemical Engineering, Hanoi University of Science and Technology
  • Tran Khac Vu School of Chemical Engineering, Hanoi University of Science and Technology
  • Tran Duy Thanh School of Chemical Engineering, Hanoi University of Science and Technology
  • Dung Dang Trung HUST
  • Ta Hong Duc (Corresponding Author) School of Chemical Engineering, Hanoi University of Science and Technology

DOI:

https://doi.org/10.54939/1859-1043.j.mst.84.2022.86-92

Keywords:

Anti-cancer drugs; Calcium alginate; Microparticle; Microfluidic device; Vorinostat.

Abstract

 Microfluidic systems are an emerging technology for the fabrication of microparticles for drug delivery systems. This study investigated the vorinostat carrying capacity of alginate microparticles generated by the microfluidic device. The efficiency of the microcapsules were examined by scanning electron microscopy, SEM, EDS-Mapping showing the change on the microcapsules surface compared with the original microparticles. Drug-excipient interaction studies using FT-IR spectroscopy showed no change in the characteristic peaks of the drug. The encapsulation efficiency is 58.8%. Overall, the present investigation corroborated successful development of microparticles of vornostat as an effective and cost-effective approach for delivery of vornostat.

References

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Published

28-12-2022

How to Cite

Ngô, T. T. T., C. T. Đặng, K. V. Trần, D. T. Trần, D. Dang Trung, and H. Đức Tạ. “Fabrication of Alginate Microparticles by Microfluidic Device for Vorinostat Anti-Cancer Agent Delivery”. Journal of Military Science and Technology, no. 84, Dec. 2022, pp. 86-92, doi:10.54939/1859-1043.j.mst.84.2022.86-92.

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